adj.不顾的;不考虑的
We will have the work done, irrespective of cost. 不管花多大代价,我们也要把这项工作做好。
He rushed toward to help, irrespective of the consequence. 他不顾后果,冲上前去帮助。
He married her, irrespective of the will of his parents. 他违背父母的意愿与她结了婚。
irrespective常与of连用,构成复合介词。